abstract：OBJECTIVE:Delay in diagnosis of endometrial cancer may be associated with disease progression and impact management and outcomes. Social and cultural barriers influence recognition of symptoms and self-advocacy in seeking care. Associations between social determinants of health (SDH) and disease presentation have been ...

journal_title：Gynecologic oncology

authors： Helpman L,Pond GR,Elit L,Anderson LN,Seow H

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:To assess the incidence of vulvar high-grade precancerous lesions and cancer in Denmark during 1997-2018. METHODS:We identified incident vulvar cancer cases in the Danish Cancer Registry and incident cases of vulvar precancerous lesions in the Danish Pathology Register. We calculated age-standardized inciden...

journal_title：Gynecologic oncology

authors： Rasmussen CL,Thomsen LT,Aalborg GL,Kjaer SK

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:To design and implement a standardized postoperative voiding management protocol that accurately identifies patients with urinary retention and reduces unnecessary re-catheterization. METHODS:A postoperative voiding management protocol was designed and implemented in patients undergoing major, inpatient, non...

journal_title：Gynecologic oncology

authors： Brackmann M,Carballo E,Uppal S,Torski J,Reynolds RK,McLean K

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:Vulvar squamous cell carcinoma (VSCC) commonly metastasises through groin lymphatics. However, the use of pre-operative imaging in detecting inguinal nodal metastasis before staging surgery or to triage patients for sentinel node biopsy remains unclear. Here, we investigated if pre-operative CT scan, the i...

journal_title：Gynecologic oncology

authors： Pounds R,O'Neill D,Subba K,Garg A,Scerif M,Leong E,Nevin J,Kehoe S,Yap J

更新日期：2020-05-01 00:00:00

abstract：:For over forty years, the Gynecologic Oncology Group drove progress in treating endometrial cancer. The first decades of investigation began with a meticulous prospective, surgicopathologic staging study that was the platform for development of all subsequent trials. The resultant statistical model of low risk, interm...

journal_title：Gynecologic oncology

authors： Miller DS,Randall ME,Filiaci V

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:Endometrial cancer (EC) is a rare condition in young women. The objective of this study was to evaluate the risk of pelvic lymph node (LN) metastasis in young women with EC who are candidates for conservative management. METHODS:Using the SEER database, a population-based analysis was conducted to identify w...

journal_title：Gynecologic oncology

authors： Gonthier C,Douhnai D,Koskas M

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:To investigate survival disparities and prognostic factors in vulvar cancer by age at diagnosis. METHODS:Women who underwent surgery and were diagnosed with stage I-IV vulvar cancer from 2004 to 2014 in the National Cancer Database were eligible. Proportions were compared using Chi-Square test. Survival was...

journal_title：Gynecologic oncology

authors： Gaulin NB,Lesnock JL,Tian C,Osei-Bonsu K,Jacobs A,Richard SD,Krivak TC,Miller EM,Shriver CD,Casablanca Y,Maxwell GL,Darcy KM

更新日期：2020-04-01 00:00:00

abstract：:The role of adjuvant chemotherapy in surgically staged stage I clear cell ovarian cancer (OCCC) is unclear. Here, we performed a systematic review and meta-analysis in order to evaluate the role of chemotherapy vs. observation in stage I OCCC. This systematic review was registered in the International Prospective Regi...

journal_title：Gynecologic oncology

authors： Bogani G,Ditto A,Lopez S,Bertolina F,Murgia F,Pinelli C,Chiappa V,Raspagliesi F

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:The first-line chemotherapy for ovarian cancer is based on a combination of platinum and taxane. To date, no reliable predictive biomarker has been recognized that is capable of identifying patients with pre-existing resistance to these agents. Here, we have established an integrated database and identified t...

journal_title：Gynecologic oncology

authors： Fekete JT,Ősz Á,Pete I,Nagy GR,Vereczkey I,Győrffy B

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Mismatch repair (MMR) deficiency and Bethesda panel microsatellite instability (MSI) are increasingly analyzed to identify tumors that might benefit from immune checkpoint inhibitors, but tumor heterogeneity is a potential obstacle for such analyses. In ovarian cancer, data on intratumoral heterogeneity of MM...

journal_title：Gynecologic oncology

authors： Fraune C,Rosebrock J,Simon R,Hube-Magg C,Makrypidi-Fraune G,Kluth M,Büscheck F,Höflmayer D,Schmalfeldt B,Müller V,Wölber L,Witzel I,Paluchowski P,Wilke C,Heilenkötter U,von Leffern I,Clauditz TS,Wilczak W,Sauter G,S

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE/BACKGROUND:Laparoscopic splenectomy is a potential surgical option for the treatment of isolated gynecologic cancer recurrence to the spleen [1-7]. The purpose of this video is to demonstrate a step-by-step approach for laparoscopic splenectomy in the setting of recurrent, oligometastatic ovarian cancer. MET...

journal_title：Gynecologic oncology

authors： Acosta-Torres S,Fader AN

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:Lymphovascular space invasion (LVSI) is an independent risk factor for recurrence and poor survival in early-stage endometrioid endometrial cancer (EEC), but optimal adjuvant treatment is unknown. We aimed to compare the survival of women with early-stage EEC with LVSI treated postoperatively with observatio...

journal_title：Gynecologic oncology

authors： Beavis AL,Yen TT,Stone RL,Wethington SL,Carr C,Son J,Chambers L,Michener CM,Ricci S,Burkett WC,Richardson DL,Staley AS,Ahn S,Gehrig PA,Torres D,Dowdy SC,Sullivan MW,Modesitt SC,Watson C,Veade A,Ehrisman J,Havril

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:Intraperitoneal (IP) chemotherapy following neoadjuvant chemotherapy (NACT) and interval tumor reductive surgery (TRS) for advanced ovarian cancer is feasible, however, the impact on disease outcomes remains unclear. We compare outcomes of patients treated with IP chemotherapy versus intravenous (IV) chemoth...

journal_title：Gynecologic oncology

authors： Bixel K,Vetter M,Davidson B,Berchuck A,Cohn D,Copeland L,Fowler JM,Havrilesky L,Lee PS,O'Malley DM,Salani R,Valea F,Alvarez Secord A,Backes F

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:The impact of gynecologic cancer on health-related quality of life (HRQOL) is not fully understood. To our knowledge, this is the first longitudinal study to measure HRQOL changes from before to after gynecologic cancer diagnosis in older women. METHODS:Data were obtained from the Surveillance, Epidemiology, a...

journal_title：Gynecologic oncology

authors： Klapheke AK,Keegan THM,Ruskin R,Cress RD

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:The benefit of adjuvant chemotherapy for Stage IC grade 1 and stage IA/IB grade 2 endometrioid ovarian adenocarcinoma (EOOC) remains unclear as the NCCN guidelines recommend either observation only or adjuvant chemotherapy. Therefore, we sought to determine whether patients with stage I EOOC had improved o...

journal_title：Gynecologic oncology

authors： Nasioudis D,Latif NA,Simpkins F,Cory L,Giuntoli RL 2nd,Haggerty AF,Morgan MA,Ko EM

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:The 2018 International Federation of Gynecology and Obstetrics (FIGO) staging system for cervical cancer changed from a clinical system to a clinical/pathologic/radiologic system with stages IIIC1 and IIIC2 indicating positive pelvic and para-aortic lymph nodes, respectively. We evaluated the National Cancer ...

journal_title：Gynecologic oncology

authors： McComas KN,Torgeson AM,Ager BJ,Hellekson C,Burt LM,Maurer KA,Werner TL,Gaffney DK

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Cyclin-dependent kinase 7 (CDK7) engages tumor growth by acting as a direct link between the regulation of transcription and the cell cycle. Here, we investigated the clinical significance of CDK7 expression and its potential as a therapeutic target in epithelial ovarian cancer (EOC). METHODS:CDK7 expression...

journal_title：Gynecologic oncology

authors： Kim J,Cho YJ,Ryu JY,Hwang I,Han HD,Ahn HJ,Kim WY,Cho H,Chung JY,Hewitt SM,Kim JH,Kim BG,Bae DS,Choi CH,Lee JW

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Early-phase data have demonstrated induction of antibody responses to a polyvalent vaccine conjugate (Globo-H, GM2, MUC1-TN, TF) with adjuvant OPT-821. We sought to determine if this combination decreases the hazard of progression or death compared to OPT-821 alone in patients with ovarian cancer in second/th...

journal_title：Gynecologic oncology

authors： O'Cearbhaill RE,Deng W,Chen LM,Lucci JA 3rd,Behbakht K,Spirtos NM,Muller CY,Benigno BB,Powell MA,Berry E,Tewari KS,Hanjani P,Lankes HA,Aghajanian C,Sabbatini PJ

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Increased Vascular Endothelial Growth Factor Receptor (VEGF) expression in endometrial cancer (EC) is associated with a poor prognosis. Preliminary clinical data reported Bevacizumab effectiveness in EC both as single agent and in combination with chemotherapy. METHODS:In a phase II trial, patients with adva...

journal_title：Gynecologic oncology

authors： Lorusso D,Ferrandina G,Colombo N,Pignata S,Pietragalla A,Sonetto C,Pisano C,Lapresa MT,Savarese A,Tagliaferri P,Lombardi D,Cinieri S,Breda E,Sabatucci I,Sabbatini R,Conte C,Cecere SC,Maltese G,Scambia G

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:To date, The Cancer Genome Atlas (TCGA) has provided the most extensive molecular characterization of invasive cervical cancer (ICC). Analysis of reverse phase protein array (RPPA) data from TCGA samples showed that cervical cancers could be stratified into 3 clusters exhibiting significant differences in sur...

journal_title：Gynecologic oncology

authors： Rader JS,Pan A,Corbin B,Iden M,Lu Y,Vellano CP,Akbani R,Mills GB,Simpson P

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:After The Cancer Genome Atlas (TCGA) findings, four novel prognostic groups may direct the management of endometrial cancer (EC): POLE-mutated/ultramutated (POLEmt), microsatellite-instable/hypermutated (MSI), copy-number-low/p53-wild-type (p53wt), and copy-number-high/p53-mutated (p53mt). However, data abou...

journal_title：Gynecologic oncology

authors： Raffone A,Travaglino A,Mascolo M,Carbone L,Guida M,Insabato L,Zullo F

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:Pegylated liposomal doxorubicin (PLD) has similar reported clinical efficacy compared with conventional doxorubicin with less cardiotoxicity. The manufacturer of PLD advises that cardiac function should be evaluated with endomyocardial biopsy, echocardiography or multigated radionucleotide scan (MUGA) pre-tre...

journal_title：Gynecologic oncology

authors： Dioun SM,Vilardo N,Goldberg GL,Gressel GM

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:To compare the survival experience of women with a BRCA1 mutation who enrolled in an ovarian cancer screening program with that of women who opted for preventive oophorectomy. METHODS:We followed 1964 women with a BRCA1 mutation and two ovaries intact in a prospective study. No women had ovarian cancer or ha...

journal_title：Gynecologic oncology

authors： Gronwald J,Lubinski J,Huzarski T,Cybulski C,Menkiszak J,Siołek M,Stawicka M,Sun P,Kim SJ,Kotsopoulos J,Narod SA

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:To compare the oncologic outcome of women who underwent fertility-sparing surgery (FSS) vs. radical surgery (RS) for treatment of NEOC in a prospective, nationwide, population-based study and report on the reproductive outcomes in women after FSS. METHODS:Using the Swedish Quality Register for Gynecological ...

journal_title：Gynecologic oncology

authors： Johansen G,Dahm-Kähler P,Staf C,Flöter Rådestad A,Rodriguez-Wallberg KA

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:The AGO-OVAR16 study was designed to test the efficacy, safety, and tolerability of pazopanib maintenance after first-line chemotherapy in patients with newly diagnosed advanced ovarian cancer (AOC). METHODS:Nine hundred and forty patients with histologically confirmed AOC, International Federation of Gyneco...

journal_title：Gynecologic oncology

authors： Vergote I,du Bois A,Floquet A,Rau J,Kim JW,Del Campo JM,Friedlander M,Pignata S,Fujiwara K,Colombo N,Mirza MR,Monk BJ,Tsibulak I,Calvert PM,Herzog TJ,Hanker LC,Meunier J,Lee JY,Bologna A,Carrasco-Alfonso MJ,Harter

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Ovarian cancer is the deadliest gynecologic malignancy, yet the effects on survival of modifiable pre-diagnosis lifestyle factors, such as obesity and physical activity, remain largely unexplored. Our objective was to evaluate the effect of pre-diagnosis BMI and physical activity on ovarian cancer mortality ...

journal_title：Gynecologic oncology

authors： Zamorano AS,Hagemann AR,Morrison L,Lee JA,Liao LM,Brinton LA,Park Y,Toriola AT

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:To estimate the frequency of abnormal surveillance cytology leading to high-grade dysplasia after surgical management for high-grade vulvar intraepithelial neoplasia (VIN) and vulvar cancer and to determine whether prior hysterectomy reduces this risk. METHODS:Women who underwent surgery for high-grade VIN ...

journal_title：Gynecologic oncology

authors： Buchanan TR,Zamorano AS,Massad LS,Liu J,Thaker PH,Powell MA,Mutch DG,Kuroki LM

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:To determine which patients with locoregionally advanced endometrial cancer may benefit from pelvic external beam radiotherapy (EBRT) in addition to chemotherapy compared to chemotherapy alone. METHODS:Patients with FIGO stages III-IVA endometrial carcinoma between 2004 and 2016 who underwent at least total...

journal_title：Gynecologic oncology

authors： Xiang M,English DP,Kidd EA

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To examine associations between post-diagnosis use of antihypertensive (AH) medications including thiazide diuretics (TDs), angiotensin converting enzyme inhibitors (ACEIs), beta blockers (BBs) [both non-selective (NSBBs) and selective (SBBs)] and calcium channel blockers (CCBs) and ovarian cancer-specific su...

journal_title：Gynecologic oncology

authors： Harding BN,Delaney JA,Urban RR,Weiss NS

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To determine the incidence of local recurrence of vulvar squamous cell carcinoma in relation to tumor- and/or precursor lesion free pathologic margins. METHODS:Consecutive patients with primary vulvar squamous cell carcinoma surgically treated in two Dutch expert centers between 2000 and 2010 were included. ...

journal_title：Gynecologic oncology

authors： Te Grootenhuis NC,Pouwer AW,de Bock GH,Hollema H,Bulten J,van der Zee AGJ,de Hullu JA,Oonk MHM

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:The value of surgical staging of apparent early stage epithelial ovarian carcinoma (EOC) is unclear. The aim of this study was to evaluate the importance of surgical staging on the stage of disease and treatment plan. MATERIAL AND METHODS:All patients with apparent stage I EOC undergoing staging from 01/01/2...

journal_title：Gynecologic oncology

authors： Hengeveld EM,Zusterzeel PLM,Lajer H,Høgdall CK,Rosendahl M

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:Describe clinical characteristics and risk reducing strategies utilized among women with a BRCA mutation who lived to age 75 and above. METHODS:A retrospective study of women with BRCA mutations identified from 1995 to 2015 in a California health care system. From a database of 1189 women, 69 participants we...

journal_title：Gynecologic oncology

authors： Salyer C,Kobelka C,Barrie A,Weintraub MR,Powell CB

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:About 30% of Adult type granulosa cell tumors of the ovary (AGCTs) are diagnosed in fertile age. In stage I, conservative surgery (fertility-sparing surgery, FSS), either unilateral salpingo-oophorectomy (USO) or cystectomy are possible options. The aim of this study is to compare oncological outcomes of FSS ...

journal_title：Gynecologic oncology

authors： Bergamini A,Cormio G,Ferrandina G,Lorusso D,Giorda G,Scarfone G,Bocciolone L,Raspagliesi F,Tateo S,Cassani C,Savarese A,Breda E,De Giorgi U,Mascilini F,Candiani M,Kardhashi A,Biglia N,Perrone AM,Pignata S,Mangili G

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To evaluate clinical outcomes of patients with BRCA-associated ovarian cancer who developed brain metastases (BM). METHODS:Patients with epithelial ovarian, fallopian tube, and primary peritoneal cancer (EOC) and BM, treated at a single institution from 1/1/2008-7/1/2018, were identified from two institution...

journal_title：Gynecologic oncology

authors： Stasenko M,Cybulska P,Feit N,Makker V,Konner J,O'Cearbhaill RE,Alektiar KM,Beal K,Gardner GJ,Long Roche KC,Sonoda Y,Chi DS,Zivanovic O,Leitao MM Jr,Cadoo KA,Tew WP

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the long-term outcomes of young early stage cervical cancer patients wishing to preserve their childbearing potential. METHODS:Data of young (aged <40 years) patients with early stage cervical cancer were prospectively collected. All patients with stage IA2, IB1 and IB2 cervical cancer were inclu...

journal_title：Gynecologic oncology

authors： Bogani G,Chiappa V,Vinti D,Somigliana E,Filippi F,Murru G,Murgia F,Martinelli F,Ditto A,Raspagliesi F

更新日期：2019-07-01 00:00:00

abstract：:Immunotherapy (IO) is an important new pillar in the treatment of solid tumors, and the integration of IO agents with chemotherapy, targeted therapy, surgery and radiation has yet to be defined. As preclinical and clinical studies have described synergistic activity with the combination of radiation and immunotherapy,...

journal_title：Gynecologic oncology

authors： Lee L,Matulonis U

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Obesity confers an overall increased risk for development of endometrial cancer. However there are conflicting reports regarding the effect of obesity on patients' overall and disease specific survival. The purpose of this study was to evaluate the effect of obesity on survival in women with endometrial canc...

journal_title：Gynecologic oncology

authors： Van Arsdale A,Miller DT,Kuo DY,Isani S,Sanchez L,Nevadunsky NS

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:According to current treatment guidelines, comprehensive surgical staging procedures in endometrial cancer confined to the uterus depend on uterine risk factors: a systematic lymph node dissection (LND) is recommended in high risk patients and should be omitted in low risk patients. Its role in intermediate ...

journal_title：Gynecologic oncology

authors： Pölcher M,Rottmann M,Brugger S,Mahner S,Dannecker C,Kiechle M,Brambs C,Grab D,Anthuber C,von Koch F,Schnelzer A,Engel J

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Improved treatment for advanced cervical cancer is needed; currently, treatment options include combined chemotherapy and bevacizumab or pembrolizumab monotherapy for PD-L1 positive disease. PIK3CA and KRAS mutations have been reported in cervical cancers; this study therefore tested dual inhibition of PI3K ...

journal_title：Gynecologic oncology

authors： Liu JF,Gray KP,Wright AA,Campos S,Konstantinopoulos PA,Peralta A,MacNeill K,Morrissey S,Whalen C,Dillon D,Matulonis UA

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:Effective communication improves patient outcomes and is crucial to good patient care. Communication skills training (CST) has been shown to improve communication skills in non-gynecologic oncology specialties. We sought to develop and test CST for gynecologic oncology (GO) providers. METHODS:We developed an...

journal_title：Gynecologic oncology

authors： Lefkowits C,Bevis K,Carey EC,Sheeder J,Arnold RM,Podgurski L

更新日期：2019-06-01 00:00:00